Faculty & Staff
Loree Heller
Education
PhD, 51在线 College of Medicine, Tampa, FL, Biochemistry and
Molecular Biology
MS, Long Island University, Greenvale, NY, Medical Microbiology and Immunology
BS, Oregon State University, Corvallis, OR, Microbiology
Research
Nucleic acid electrotransfer, Non-viral gene therapies, Pattern recognition receptors
Memberships
American Society for Clinical Pathology
American Society of Gene and Cell Therapy
American Association of Immunologists
American Association for Cancer Research
National Academy of Inventors
International Society for Electroporation
Research Grants
NIH NCI R01 鈥淒NA-specific pattern recognition receptor activation following DNA electroporation鈥�
Recent Publications
Conniff, Amanda & Cason, Aneeshea & Alvarado, Juliana & Bhandary, Manya & Patel, Shreena & Singh, Julie & Heller, Richard & Heller, Loree. (2024). Direct Plasmid DNA Transfection into Differentiated Mouse C2C12 Myotubes. Re:GEN Open. 4. 1-8. 10.1089/regen.2023.0026.
Conniff, Amanda & Tur, Jared & Kohena, Kristopher & Zhang, Min & Gibbons, Justin & Heller, Loree. (2023). DNA Electrotransfer Regulates Molecular Functions in Skeletal Muscle. Bioelectricity. 10.1089/bioe.2022.0041.
Sales, Amanda & Tur, Jared & Kohena, Kristopher & Zhang, Min & Gibbons, Justin & Heller, Loree. (2022). Transcriptomic Analysis of the Acute Skeletal Muscle Effects after Intramuscular DNA Electroporation Reveals Inflammatory Signaling. Vaccines. 10. 2037. 10.3390/vaccines10122037.
Bhandary, Manya & Sales, Amanda & Miranda, Kaitlyn & Heller, Loree. (2022). Acute Effects of Intratumor DNA Electrotransfer. Pharmaceutics. 14. 2097. 10.3390/pharmaceutics14102097.
Sales, Amanda & Encalada, G & Patel, S & Bhandary, M & Al-Takrouri, F & Heller, Loree. (2022). Poly(I:C) transfection induces a pro-inflammatory cascade in murine mammary carcinoma and fibrosarcoma cells. RNA Biology. 19. 841-851. 10.1080/15476286.2022.2084861.
Heller, Loree & Shi, Guilan & Synowiec, Jody & Heller, Richard. (2022). Abstract 3289: PD-1 peptide/IL-12 combination gene therapy for the treatment of melanoma. Cancer Research. 82. 3289-3289. 10.1158/1538-7445.AM2022-3289.
Bo拧njak, Ma拧a & Znidar, K. & Sales, Amanda & Jesenko, Tanja & Markelc, B. & Semenova, Nina & Tur, J. & Kohena, K. & Kranjc, Simona & Heller, Loree & Cemazar, Maja. (2022). In vitro and in vivo correlation of skin and cellular responses to nucleic acid delivery. Biomedicine & Pharmacotherapy. 150. 113088. 10.1016/j.biopha.2022.113088.
Heller, Loree & Znida, Katarina & Bo拧njak, Ma拧a & Sales, Amanda & Jesenko, Tanja & Markelc, Bostjan & Tur, Jared & Semenova, Nina & Cemazar, Maja. (2022). Comparison of DNA sensing by non-immune cells and tissues. The Journal of Immunology. 208. 164.06-164.06. 10.4049/jimmunol.208.Supp.164.06.
Heller, Loree & Bulysheva, Anna & Arpag, S. & Sales, Amanda & Kohena, K. & Shi, G. & Semenova, Nina & Heller, Richard & Cemazar, Maja. (2021). Growth environment influences B16.F10 mouse melanoma cell response to gene electrotransfer. Bioelectrochemistry. 140. 107827. 10.1016/j.bioelechem.2021.107827.
Dolezalova, Eva & Malik, Muhammad & Heller, Loree & Heller, Richard. (2021). Delivery and expression of plasmid DNA into cells by a novel non-thermal plasma source. Bioelectrochemistry. 140. 107816. 10.1016/j.bioelechem.2021.107816.
Bulysheva, Anna & Heller, Loree & Francis, Michael & Varghese, Frency & Boye, Carly & Heller, Richard. (2021). Monopolar Gene Electrotransfer Enhances Plasmid DNA Delivery to Skin. Bioelectrochemistry. 140. 107814. 10.1016/j.bioelechem.2021.107814.
Jesenko, Tanja & Bo拧njak, Ma拧a & Markelc, Bostjan & Sersa, Gregor & Znidar, Katarina & Heller, Loree & Cemazar, Maja. (2020). Radiation Induced Upregulation of DNA Sensing Pathways is Cell-Type Dependent and Can Mediate the Off-Target Effects. Cancers. 12. 10.3390/cancers12113365.
Heller, Loree & Thinard, Reynald & Chevalier, Melanie & Arpag, Sezgi & Jing, Yu & Greferath, Ruth & Heller, Richard & Nicolau, Claude. (2020). Secretion of proteins and antibody fragments from transiently transfected endothelial progenitor cells. Journal of Cellular and Molecular Medicine. 24. 10.1111/jcmm.15511.
PATENTS
US 6,714,816 B1 (Issued March 30, 2004): Electroporation and electrophoresis system and method for achieving molecular penetration into cells in vivo. Inventors: Heller R, Gilbert R, Jaroszeski MJ, Heller LC, Lucas ML. Assignee: 51在线.
US 7,668,592 B2 (Issued February 23, 2010): Electroporation and electrophoresis system and method for achieving molecular penetration into cells in vivo. Inventors: Heller R, Gilbert R, Jaroszeski MJ, Heller LC, Lucas ML. Assignee: 51在线.
US 8,802,643 (Issued August 12, 2014) Method for the treatment of malignancies, Inventors: Heller, R., Heller, L.C. Assignee: 51在线.
US 8,895,248 (Issued November 25, 2014) Method for Detecting Salmonella Species By Assaying Outer Membrane Porin F (ompF). Inventors: Tatavarthy, A., Cannons, A.C., and Heller, L.C. Assignee: 51在线.
US 9,410,212 (Issued August 9, 2016) Kit for Detecting Salmonella Species By Assaying Outer Membrane Porin F (ompF). Inventors: Tatavarthy, A., Cannons, A.C., and Heller, L.C. Assignee: 51在线. https://www.google.com.ar/patents/US9410212
US 9,610,364 (Issued April 4, 2017) Method for the treatment of malignancies, Inventors: Heller, R., Lucas, M.L., Heller, L.C. Assignee: 51在线.